Basic scientific and normal volunteer studies

 

1. Schobersberger W, Mittermayr M, Fries D, Innerhofer P, Klingler A, Faulhaber M, Gunga HC, Streif W. Changes in blood coagulation of arm and leg veins during a simulated long-haul flight. Thrombosis Research. 119(3):293-300, 2007 Apr.

 

2. Toff WD, Jones CI, Ford I, Pearse RJ, Watson HG, Watt SJ, Ross JA, Gradwell DP, Batchelor AJ, Abrams KR, Meijers JC, Goodall AH, Greaves M. Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation. Journal of the American Medical Association. 295(19):2251-61, 2006 May 17. Erratum in: JAMA. 296(1):46, 2006 Jul 5.

 

3. Schiffer T, Struder HK, Predel HG, Hollmann W. Effects of mild leg exercise in a seated position on haemostatic parameters under normobaric hypoxic conditions. Canadian Journal of Applied Physiology. 30(6):708-22, 2005 Dec.

 

4. Hodkinson PD, Hunt BJ, Parmar K, Ernsting J. Is mild normobaric hypoxia a risk factor for venous thromboembolism? Journal of Thrombosis and Haemostasis. 1: 2131-2133, 2003 Oct.

 

5. Crosby A, Talbot NP, Harrison P, Keeling D, Robbins PA. Relation between acute hypoxia and activation of coagulation in human beings. Lancet. 361:2207-8, 2003 Jun 28.

 

6. Stricker H, Colucci G, Godio M, Mossi G, Mombelli G. The influence of a prolonged sitting position on the biochemical markers of coagulation activation in healthy subjects: evidence of reduced thrombin generation. Journal of Thrombosis and Haemostasis. 1: 380-99, 2003 Feb.

 

7. Chan WK, Wong YW, Yu SC, Chua LP.  A computational study of the effects of inlet guide vanes on the performance of a centrifugal blood pump. Artificial Organs. 26:534-42, 2002 Jun.

 

8. Mannucci PM, Gringeri A, Peyvandi F, Di Paolantonio T, Mariani G. Short-term exposure to high altitude causes coagulation activation and inhibits fibrinolysis. Thrombosis and Haemostasis. 87: 342-3, 2002 Feb.

 

9. Bendz B. Sevre K. Andersen TO. Sandset PM. Low molecular weight heparin prevents activation of coagulation in a hypobaric environment. Blood Coagulation & Fibrinolysis. 12:371-374, 2001 Jul.

 

10. Bartsch P, Straub PW, Haeberli A. Hypobaric hypoxia. Lancet. 357:955-6, 2001 Mar. followed by responses by Bendz and other correspondents.

 

11. Hitosugi M. Niwa M. Takatsu A. Rheologic changes in venous blood during prolonged sitting. Thrombosis Research. 100: 409-412, 2000.

 

12. Bendz B. Rostrup M. Sevre K. Andersen TO. Sandset PM. Association between acute hypobaric hypoxia and activation of coagulation in human beings. Lancet, 356: 1657-1658, 2000.

 

13. Tardy B. Tardyponcet B. Bara L. Laportesimitsidis S. Rascle F. Samama MM. Guyotat D. Bertrand JC. Effects of long travels in sitting position in elderly volunteers on biological markers of coagulation activation aand fibrinolysis. Thrombosis Research. 83:153-160, 1996.

 

14. Cottrell JJ. Lebovitz BL. Fennell RG. Kohn GM. Inflight arterial saturation - continuous monitoring by pulse oximetry. Aviation Space and Environmental Medicine. 66: 126-130, 1995.

 

15. Landgraf H. Vanselow B. Schultehuermann D. Mulmann MV. Bergau L. Economy class syndrome - rheology, fluid balance, and lower leg edema during a simulated 12-hour long distance flight.  Aviation Space & Environmental Medicine.65:930-935, 1994.

 

16. Doughty HA. Beardmore C. Bleeding time at altitude. Journal of the Royal Society of Medicine. 87:317-319, 1994.

 

17. Noddeland H. Winkel J. Effects of leg activity and ambient barometric pressure on foot swelling and lower-limb skin temperature during 8 h of sitting. European Journal of Applied Physiology & Occupational Physiology. 57:409-14, 1988.

 

18. Makris PE, Louizou C, Markakis C, Tsakiris DA, Mandalaki T. Long lasting sitting position and haemostasis.Thrombosis and Haemostasis. 55:119-21, 1986 Feb 28.